Sorafenat 200mg tablet - Sorafenib Uses & Side effects

Sorafenat 200mg Tablet



Sorafenib is pharmacologically categorized as protein kinase inhibitor, which is FDA approved compound used for the treatment of primary renal cell cancer in advanced stage, metastatic liver carcinoma (sorafenib liver cancer) and also involved in radioactive iodine resistant advanced thyroid cancer.

Sorafenib is considered as synthetic compound aiming signal responding for growth and angiogenesis. Sorafenib works by blocking the enzyme RAF kinase, which is a demanding component of the RAF/MEK/ERK signaling pathway that dominates cell separation and multiplication. On the other hand, Sorafenib also prohibits the VEGFR-2/PDGFR-beta signaling force, through blockade of tumor angiogenesis.


PRODUCT DETAILS

Brand               Sorafenat
Ingredients       Sorafenib
Strength               200mg
Manufactured       Natco


Sorafenat 200mg tablet
Sorafenat 200mg tablet


SORAFENAT (SORAFENIB) MECHANISM OF ACTION

The activity of Sorafenat 200mg tablet containing Sorafenib is developing in-vitro. Sorafenat expels its activity by prohibiting assorted intracellular & cell surface kinase which is important for tumor cell signaling exudation, angiogenesis and apoptosis. 

Due to prohibition of these multikinases is a source of cancer growth termination. Reduction of cancer cell angiogenesis happens in HCC, RCC and elevation of cancer cell apoptosis occurs in HCC, RCC & TC


SORAFENAT TABLET CAUSES SOME ADVERSE EFFECTS

Hypertension Myocardial infarction or ischemia Gastrointestinal perforation Drug caused hepatitis Hemorrhage

MOST COMMON SIDE EFFECTS (SORAFENIB)

Diarrhea, Alopecia, Infection, Hand foot skin reaction, Musculoskeletal disorders, Loss of weight, Increasing amylase & lipase

POST MARKETING ADVERSE EFFECTS

Stevens Johnson syndrome, Angioedema, Rhabdomyolysis, Osteonecrosis, Interstitial lung disease, Folliculitis, Leucopenia, Neutropenia, Anemia, Thrombocytopenia, Hypothyroidism, Hypocalcaemia, Hypokalemia, Hyponatremia, Depression, Peripheral sensory neuropathy, Tinnitus, Congestive heart failure, Rhinorrhoea, Dysphonia, Gastro esophageal reflux


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